Manufacturer: Sanofi-Synthelabo, Inc. Drug Class: Platinum antineoplastic agent Description: Oxaliplatin for injection is an organoplatinum complex in which the platinum atom is joined with 1,2-diamino-cyclohexane (DACH) and with an oxalate ligand as a “leaving group,” an atom (or group of atoms) that is displaced as stable species and takes the bonding electrons with it. Oxali-platin [...]

Manufacturer: Eli Lilly Drug Class: Antifolate antineoplastic agent Description: Pemetrexed for injection exerts its action by disrupting folate-dependent metabolic processes that are essential for cell replication. By inhibiting dihydrofolate reduc-tase, thymidylate synthase, and glycinamide ribonucleotide formyl transferase, it interrupts the de novo synthesis of both purines and pyrimidines. As a single agent, it is active [...]

Cetuximab (Erbitux™) for IV Use Only Manufacturer: Imclone Systems, Inc./Bristol-Myers Squibb Drug Class: Recombinant, human/mouse chimeric monoclonal antibody Description: Cetuximab binds specifically to the extracellular domain of human epidermal growth factor receptor (EGFR). Produced in mammalian (murine myeloma) cell culture, cetuximab is composed of the fragment variable (Fv) regions of a murine anti-EGFR antibody with [...]