Hepatitis B Virus (HBV)

Tag: Asthma

Ketotifen in the Prophylaxis of Extrinsic Bronchial Asthma: Conclusion

Although this procedure inescapably compounds differences based upon monitoring of symptoms (ie, drug usage is reduced until symptoms appear). Results of the present study show that 42 percent of the patients receiving slow-release oral ketotifen were able to reduce (or, in some cases, stop) the amount of additional antiasthmatic drug therapy, compared to 27 percent […]

Ketotifen in the Prophylaxis of Extrinsic Bronchial Asthma: Discussion

Ketotifen in the Prophylaxis of Extrinsic Bronchial Asthma: Discussion

Ketotifen (Zaditen or Zasten) is a benzocylohepta-thiophene derivation that is orally active; it is metabolized in humans to the glucuronide and desmethyl derivatives, both of which are excreted in the urine. Clinical studies have shown ketotifen to be effective in the treatment of asthma when compared with placebo, theophylline, and cromoglycate, and to have steroid-sparing […]

Figure 3. Changes of PEFR. No statistically significant difference between two groups was seen (Mann-Whitney rank-sum test).

Ketotifen in the Prophylaxis of Extrinsic Bronchial Asthma: Efficacy

Efficacy The intensity of asthmatic attacks during the day and night, as well as the total number of days with asthmatic attacks, decreased during treatment in both groups. At the end of treatment, there was a statistically significant difference between the two groups in favor of slow-release oral ketotifen. A Mann-Whitney rank-sum test with significance […]

Ketotifen in the Prophylaxis of Extrinsic Bronchial Asthma: Results

Ketotifen in the Prophylaxis of Extrinsic Bronchial Asthma: Results

Statistical Analysis According to the type and distribution of the data, either parametric tests (Students f-test) or nonparametric analyses (Wil-coxon-Mann-Whitney U-test) were utilized. In x* tests, ā€œn-1ā€ replaced ā€œnā€ in the formula used for continuity correction of 2 x 2 tables. The level of significance was defined with alpha=0.05 (two-sided tests), but if the difference […]

Ketotifen in the Prophylaxis of Extrinsic Bronchial Asthma: Design of Study

Design of Study The study was a double-blind, randomized, controlled multicenter study (22 centers in nine European countries) comparing a slow-release oral formulation of ketotifen with placebo for a period of 12 weeks in patients with mild extrinsic bronchial asthma. The dosing regimen for the slow-release oral tablet of ketotifen was based on the known […]

Ketotifen in the Prophylaxis of Extrinsic Bronchial Asthma

Ketotifen in the Prophylaxis of Extrinsic Bronchial Asthma

A Multicenter Controlled Double-Blind Study with a Modified-Release Formulation Ketotifen (Zaditen or Zasten) is widely used as a prophylactic drug in the treatment of extrinsic bronchial asthma, with the exception of the United States. In controlled studies, efficacy has been detected in the majority (50 to 70 percent) of patients. The only prominent side effect […]

Comparison of Responses to Methacholine and Cold Air in Patients Suspected of Having Asthma: Conclusion

We therefore believe that in patients thought to have asthma, although responses to cold air and methacholine are related, the relationship is by no means perfect, response to one agent explaining something on the order of 25 percent of the variation in response to the other. These results are not entirely unprecedented. In their studies […]

Tags