Pretreatment with catecholamines can suppress severe ventricular arrhythmias in rats: RESULTS (part 3)
Hemodynamic effects of noradrenaline: Infusion of noradrenaline in the isolated hearts caused a transient increase in heart rate and in perfusion pressure by approximately 15% to 20%. These effects, however, were short-lasting and completely disappeared by the end of a 10 min washout period.In the in vivo experiments 24 h after administration of noradrenaline, there were no differences in basic hemodynamic parameters between the pretreated and untreated animals before the induction of ischemia.Pase activity: No differences in the enzyme activity in the heart sarcolemmal fraction between the control and noradrenaline-treated groups were observed before the induction of ischemia in either isolated hearts or hearts of anesthetized animals (Figure 6A,B). After 30 mins ischemia, the activity of Na+/K+-ATPase was considerably depressed in both untreated groups, and more pronounced in the Langen-dorff-perfused hearts. After both types of treatment with noradrenaline, there was no decrease in enzyme activity after ischemia. In the Langendorff-perfused hearts (Figure 6A) it was maintained at the initial preischemic level (with a tendency to a slight increase), whereas in the in vivo hearts it was even significantly enhanced compared with untreated and treated controls before ischemia (Figure 6B).
Figure 6 The effect of noradrenaline (NA) on sarcolemmal Na+/K+-ATPase activity in rat heart subjected to ischemia compared with untreated controls (C). A Acute effect of pretreatment with noradrenaline before and after ischemia. B Delayed effect of pretreatment with noradrenaline before and after ischemia. Data are means ± SEM of 9 to 12 experiments expressed in цmol ATP/mg protein (prot)/h. *P<0.05 versus nonischemic untreated group; tp<0.05 versus nonischemic NA-treated group; $P<0.05 versus ischemic untreated group
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