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Pretreatment with catecholamines can suppress severe ventricular arrhythmias in rats: RESULTS (part 3)

Hemodynamic effects of noradrenaline: Infusion of noradrenaline in the isolated hearts caused a transient increase in heart rate and in perfusion pressure by approximately 15% to 20%. These effects, however, were short-lasting and completely disappeared by the end of a 10 min washout period.In the in vivo experiments 24 h after administration of noradrenaline, there were no differences in basic hemodynamic parameters between the pretreated and untreated animals before the induction of ischemia.Pase activity: No differences in the enzyme activity in the heart sarcolemmal fraction between the control and noradrenaline-treated groups were observed before the induction of ischemia in either isolated hearts or hearts of anesthetized animals (Figure 6A,B). After 30 mins ischemia, the activity of Na+/K+-ATPase was considerably depressed in both untreated groups, and more pronounced in the Langen-dorff-perfused hearts. After both types of treatment with noradrenaline, there was no decrease in enzyme activity after ischemia. In the Langendorff-perfused hearts (Figure 6A) it was maintained at the initial preischemic level (with a tendency to a slight increase), whereas in the in vivo hearts it was even significantly enhanced compared with untreated and treated controls before ischemia (Figure 6B).

Pretreatment with catecholamines can suppress severe ventricular arrhythmias in rats

Figure 6 The effect of noradrenaline (NA) on sarcolemmal Na+/K+-ATPase activity in rat heart subjected to ischemia compared with untreated controls (C). A Acute effect of pretreatment with noradrenaline before and after ischemia. B Delayed effect of pretreatment with noradrenaline before and after ischemia. Data are means ± SEM of 9 to 12 experiments expressed in цmol ATP/mg protein (prot)/h. *P<0.05 versus nonischemic untreated group; tp<0.05 versus nonischemic NA-treated group; $P<0.05 versus ischemic untreated group 
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Category: Cardiology

Tags: Catecholamines, Na+/K+ -ATPase, Preconditioning, Ventricular arrhythmias

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