Pretreatment with catecholamines can suppress severe ventricular arrhythmias in rats: RESULTS (part 2)
In vivo studies: In the control group, the mortality of animals during ischemia was 22%, and 67% exhibited VF (Figure 3). In the noradrenaline-pretreated group, all rats survived is chemia, and VF occurred in only 11%. PVCs were significantly reduced in the noradrenaline-pretreated group to 650±150 from 1654±300 in controls (P<0.05). All of the pretreated animals exhibited brief, but significantly shorter, episodes of VT (Figure 4).
Accordingly, the severity of arrhythmias was significantly lower in both experiments (Figure 5). After acute administration of noradrenaline it was reduced to 1.8 ±0.4 from 3.9 ±0.8 in the control group (P<0.01). It was also attenuated 24 h after pretreatment with noradrenaline (3.1 ±0.1 versus 3.9±0.2 in controls, P<0.05).
Figure 3 Incidence of ischemia-induced ventricular fibrillation (VF) and mortality in anesthetized rats. Data are means ± SEM of 18 experiments. C Untreated controls; NA Noradrenaline. P versus untreated controls
Figure 4 Incidence and duration of ischemia-induced ventricular tachycardia in anesthetized rats. Data are means ± SEM of 18 experiments. C Untreated controls; NA Noradrenaline. P versus untreated controls
Figure 5 The effect of noradrenaline (NA) on the severity of ischemia-induced arrhythmias in rat heart compared with untreated controls (C). Left Acute effect; Right Delayed effect. Data are means ± SEMof15 to 18 experiments. P versus untreated controls
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