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Figure 1. Invasive pulmonary aspergillosis in patient l with leukemia and no bone marrow recovery A left': Thrombosis of a pulmonary artery by Aspergillus hvphae (arrwsj without inflammatory disruption of the vessel wall. Surrounding pulmonary parenchyma shows hemorrhagic infarction (hematoxylin and eosin stain, original magnification x 2.5). B (right): Invasion and disruption of a pulmonary artery wall by Aspergillus hyphae (arrows) without granulocytic inflammation (periodic acid-Schiff stain, original magnification, x230.)

Factors Associated with Fatal Hemoptysis in Cancer Patients: Results

Classification Patients were grouped by the type of neoplasm: hematologic malignancy or solid tumor. These groups were further subdivided by the severity of hemoptysis: fatal hemoptysis or nonfatal hemoptysis. Inadequate documentation of the quantity of hemoptysis in the medical records prevented further grading of the severity of hemoptysis. Statistical Analysis Differences in frequencies of various […]

Factors Associated with Fatal Hemoptysis in Cancer Patients

Factors Associated with Fatal Hemoptysis in Cancer Patients

Pulmonary hemorrhage occurs frequently in patients with neoplastic diseases and may become life-threatening in a significant proportion of these patients. The factors contributing to the development of fatal pulmonary hemorrhage in patients with malignant disease have not been well delineated. To address these issues, we reviewed the clinical records and available pathologic specimens from patients […]

Rapid Mucosal Absorption of Topical Lidocaine During Bronchoscopy in the Presence of Oral Candidiasis: Conclusion

Rapid Mucosal Absorption of Topical Lidocaine During Bronchoscopy in the Presence of Oral Candidiasis: Conclusion

These values are total concentrations, both bound and free lidocaine, and give no information about free fraction, which we did not investigate. The major plasma protein which binds lidocaine and several other basic drugs, alpha!-acid glycoprotein is an acute-phase protein that is elevated in certain situations such as stress, neoplastic disease, acute and chronic inflammatory […]

Rapid Mucosal Absorption of Topical Lidocaine During Bronchoscopy in the Presence of Oral Candidiasis: Discussion

This case is remarkable in that lidocaine solution and jelly applied to the oropharynx and bronchial tree were rapidly and extensively absorbed attaining a peak plasma concentration of 7.1 μg/ml within 0.67 hour of the start of drug administration (Fig 1). Furthermore, for four hours after the procedure, the plasma levels remained greater than 1.5 […]

Figure 1. Plasma lidocaine concentrations before, during, and after bronchoscopy. Arrows mark beginning and end of the bronchoscopy procedure. Bar graphs show doses and times of administration of lidocaine solution by atomizer (hatched bar), lidocaine jelly (solid bar), and lidocaine solution through the bronchoscope (open bar).

Rapid Mucosal Absorption of Topical Lidocaine During Bronchoscopy in the Presence of Oral Candidiasis

Systemic absorption of lidocaine following its topical application during diagnostic procedures can produce central nervous system or cardiac toxicity. Objective signs of toxicity are more likely at plasma concentrations above 6 μml, which are only rarely reported during bronchoscopy. It is useful, therefore, to identify patient populations at risk for developing these undesired effects due […]

Pulmonary Amyloidosis with Pulmonary Arteriovenous Fistula: Discussion

Discussion Amyloid deposition in the vascular wall is commonly seen in amyloidosis and is known to make vessels fragile. Amyloidosis has been reported to cause massive hemorrhage in the skin, urinary bladder, gastrointestinal tract, and central nervous system.* As for pulmonary amyloidosis, amyloid deposition in the vascular wall is well known in diffuse septal amyloidosis. […]

The Value of Bronchial Washings and Bronchoalveolar Lavage in the Diagnosis of Lymphangitic Carcinomatosis: Results

Twelve patients with lymphangitic carcinomatosis who satisfied the criteria for inclusion and exclusion in this study were identified. There were ten women and two men whose ages ranged from 37 to 74 years, with a mean of 58 years (Table 1). The primary lesion was adenocarcinoma of the breast in eight (67 percent) of the […]

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