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Antibiotic Therapy of Pulmonary Infections In Cystic Fibrosis

Antibiotic Therapy of Pulmonary Infections In Cystic Fibrosis

Dotage Schedules and Duration of Tteatment It is widely agreed that antibiotic therapy is beneficial in the treatment of exacerbations of pulmonary infections in patients with cystic fibrosis (CF). Frequent antibiotic treatments have been shown to increase patient survival. Randomized, double-blind, crossover trials, which have shown the benefit of antibiotic therapy in acute exacerbations in […]

The Value of Bronchial Washings and Bronchoalveolar Lavage in the Diagnosis of Lymphangitic Carcinomatosis: Discussion

The Value of Bronchial Washings and Bronchoalveolar Lavage in the Diagnosis of Lymphangitic Carcinomatosis: Discussion

Diffuse interstitial pulmonary infiltrates in patients with underlying malignant disease has a wide differential diagnosis. Transbronchial lung biopsy has been advocated as being the procedure of choice for establishing the diagnosis. Ventilation-perfusion lung scan demonstrating an irregular peripheral perfusion defect has been suggested to be helpful in raising the suspicion of lymphangitic carcinomatosis but has […]

The Value of Bronchial Washings and Bronchoalveolar Lavage in the Diagnosis of Lymphangitic Carcinomatosis

The Value of Bronchial Washings and Bronchoalveolar Lavage in the Diagnosis of Lymphangitic Carcinomatosis

In patients with underlying neoplastic disease, the presumptive diagnosis of lymphangitic carcinomatosis is usually based on a characteristic but not pathognomonic radiographic pattern of progressive diffuse reticular interstitial pulmonary infiltration with or without hilar enlargement. Invasive diagnostic procedures that are used to confirm the diagnosis include open lung biopsy, percutaneous aspiration needle biopsy, and transbronchial […]

Factors Associated with Fatal Hemoptysis in Cancer Patients: Conclusion

In patients with a primary bronchogenic tumor, fatal hemoptysis was frequently associated with a necrotic squamous cell carcinoma. Previously, investigators have shown an increased tendency in this cell type to cause tissue necrosis and subsequent hemorrhagic infarction. A proposed mechanism for the development of necrosis in squamous cell carcinoma is tumor invasion of vascular structures […]

Factors Associated with Fatal Hemoptysis in Cancer Patients: Outcome

Factors Associated with Fatal Hemoptysis in Cancer Patients: Outcome

Candida spp may also play a causative role in pulmonary hemorrhage as demonstrated by two patients with hemoptysis and a Candida pneumonia. One of these patients had a C tropicalis pneumonia and developed fatal hemoptysis, whereas the patient with a C albicans pneumonia experienced only selflimited hemoptysis. The increased virulence of C tropicalis has been […]

Factors Associated with Fatal Hemoptysis in Cancer Patients: Discussion

Unfortunately, diagnosis of fungal infections is difficult in immunocompromised patients. An antemor-tem diagnosis of fungal pneumonia was achieved in seven of eight patients in our study, but in two patients this diagnosis was made only from a sputum culture relatively late in the clinical course. Further, autopsies were not performed on all of our patients, […]

Factors Associated with Fatal Hemoptysis in Cancer Patients: Solid Tumors

Factors Associated with Fatal Hemoptysis in Cancer Patients: Solid Tumors

Solid Tumors The clinical characteristics of patients with fatal hemoptysis or nonfatal hemoptysis are presented in Table 3. The two groups contained similar proportions of patients with a bronchogenic carcinoma or a malignancy metastatic to the lung. Two patients with esophageal carcinoma and contiguous extension to the tracheobronchial tree had fatal hemoptysis. In patients with […]

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