New insights into the role of nitric oxide in cardiovascular protection (part 6)
Recently, in accordance with these observations, the appearance of EPR-detectable myoglobin-nitric oxide was found in S-nitrosoglutathione-pretreated rat hearts, after prolonged ischemia, but not in nonischemic hearts . Both LPS and S-nitrosoglutathione pretreatment are associated with cardioprotection against ischemia-reperfusion injury.Therefore, it might be suggested that stimulated nitric oxide production during a preischemic period may lead to the formation of heme (and perhaps nonheme-like in vascular tissue) nitrosyl iron complexes during a long lasting ischemia, and these complexes may play a beneficial role against the injury that occurs during reperfusion (Figure 1).There are several potential mechanisms by which nitrosyl iron complex formation may contribute to cardioprotection. Complexes such as myoglobin-nitric oxide exert antioxidant properties through direct scavenging of oxygen free radicals , which are believed to play a critical role in ischemia-reperfusion damage , and/or modulate the activity of pro-oxidant heme-containing enzymes such as lipoxygenases, cyclooxygenases or cytochromes P450 . Additionally, nitric oxide through formation of complexes with nonheme iron might contribute to the inhibition of iron(II)-dependent generation of hydroxy radicals and/or to modulate the activity of some critical thiol-containing enzymes. It’s your turn to benefit from the shopping whenever you need efficient buy allegra online that will be sure to work for your problem. This is now all very much possible at the best online pharmacy you have ever come across offering it services to you and other international customers interested.
Figure 1 Scheme of the potential role of nitrosyl iron heme and nonheme derivatives in cardioprotection. Stimulated nitric oxide production during the preischemic period may lead to the formation of nitrosyl iron complexes during long lasting ischemia, and these complexes may play a beneficial role against the injury that occurs during reperfusion. ACh Acetylcholine; BK Bradykinin; IL-1 Interleukin-1; LPS Lipopolysaccahride; ROS Reactive oxygen species