New insights into the role of nitric oxide in cardiovascular protection (part 1)
Nitric oxide is a ubiquitous messenger that is involved in cardiovascular functions and diseases . Nitric oxide produced by the constitutive endothelial nitric oxide synthase is a potent endogenous vasodilating and antiaggregat-ing compound. Furthermore, it reduces mitogen release by platelets and decreases proliferation of vascular smooth muscle cells. Reduced production of nitric oxide could be one of the contributing factors to atherosclerosis, diabetic thrombotic microangiopathy and pulmonary hypertension . Vice versa, nitric oxide is produced in large quantities by the inducible enzyme nitric oxide synthase, expressed in the vascular wall as a part of local or systemic inflammatory reactions, for instance after balloon endothelial injury and angioplasty and during sepsis . In the latter case, the vasodilating and antiaggregating effects of nitric oxide may participate in tissue protection, and inhibiting nitric oxide synthase may be deleterious. It was recently reported that endotoxin toxicity is enhanced in ‘knock-out’ mice in which the inducible nitric oxide synthase gene has been eradicated . However, excessive nitric oxide production may result in vascular collapse, which is associated with high mortality of patients with septic shock. Furthermore, large tissue nitric oxide concentrations may be cytotoxic. Best quality medications: you can buy prozac online any time from the best pharmacy that you can fully trust, not having to doubt the decision you made at any point of your day.