Modulation of 72-Kilodalton Type IV Collagenase (Matrix Metalloproteinase-2) by Ascorbic Acid in Cultured Human Amnion-Derived Cells(1)
Premature rupture of chorioamniotic membranes (PROM) is an obstetric complication that is present in 217% of all pregnancies. The highest prevalence of PROM has been linked to populations with low socioeconomic conditions. As a consequence, the search for causal determinants of PROM has focused on factors associated with adverse socioeconomic status, such as urogenital infections and malnutrition and/or specific dietary deficiencies. Buy Asthma Inhalers Online
The participation of vitamin C in the development of PROM has been suggested owing to its well-described role in the biosynthesis of collagen, the main structural constituent of chorioamniotic membranes. This hypothesis has been partially supported by the findings of low mechanical resistance and decreased collagen concentrations in samples of fetal membranes that ruptured prematurely. An association between marginal deficiency of vitamin C and PROM was found in a cross-sectional study. In addition, a relationship between low concentrations of leukocyte ascorbic acid at Week 28 of pregnancy and later development of PROM was reported in a recent prospective study.