• 22
    Feb
  • Localized Pseudoxanthoma Elasticum-like Changes on the Chin: CASE REPORT

A 60-year-old female presented with a 10-year history of pruritus on the chin. She did not have a family history of PXE. Her past medical history was unremarkable. The physical examination reĀ­vealed no skin lesions, but she complained of a severe itching sensation on the chin of more than 10 years duration (Fig. 1). A punch biopsy specimen from the chin showed short, irregularly thickened, basophilic fibers in the mid-dermis (Fig. 2A). Accumulations of swollen and irregularly clumped fibers stained deep black with Verhoeffs stain (Fig. 2B).

Fig. 1. A 60-year-old female

Fig. 1. A 60-year-old female with a 10-year history of pruritus on the chin.

Staining for calcium with von Kossa was positive in the abnormal fibers (Fig. 2C). We recommended that she see an ophthalmologist for an ocular examination, but she did not keep the follow-up visit with us.
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Fig. 2. (A) Within the mid-dermis

Fig. 2. (A) Within the mid-dermis there are numerous small, fragmented, distorted elastic fibers (H&E stain, x400). (B) Accumulation of swollen and irregularly clumped fibers staining deeply black with VerhoefPs stain (x400). (C) Staining for calcium with the von Kossa method was positive (x400).

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