Leukocyte Migration Inhibition in Propranolol-induced Pneumonitis
Bronchospasm in patients with chronic bronchitis or asthma is the most frequent adverse respiratory effect of beta-blockers. However, a few cases of pneumonitis with or without pleural effusion also have been described. The case reported herein is, to the best of our knowledge, the second case of pneumonitis due to a widely used beta blocker, propranolol. Clinical and radiologic data, results of pulmonary function tests and BAL, as well as the outcome of the disease, were in favor of an immunologic mechanism of cell-mediated hypersensitivity.
A sensitive photoelectric method for measuring cell migrations was used to assess leukocyte migration inhibition in presence of the drug; the patient s lymphocytes appeared to produce a factor inhibiting the migration of peripheral blood leukocytes (LIF) when cultured with optimal drug concentrations, suggesting the existence of a cellular response which could possibly play a role in the pathogenesis of the lung disorder. viagra plus