• 2
    May
  • Excessive Daytime Sleepiness in Chronic Obstructive Pulmonary Disease: RESULTS

Table 1 presents a comparison of the age, weight, and waking respiratory measures. Overall (n=14), there was no significant correlation between mean sleep onset latencies on the MSLT and waking Pa02 (- .13), PaC02 (.02), FEV, (.04), or mean spontaneous desaturation during sleep (.31). The mean sleep onset latencies were well within the published normal range as well as the normal range for our laboratory (unpub­lished data). Only two subjects exhibited a single sleep onset REM period.

Table 1—Waking Respiratory Measures (N=14)

Mean ± SD

Age, у

60.9 ±6.81

Weight, kg*

83.9 ±24.8

Pa02, mm Hg

62.9 ±5.2

PaC02, mm Hg

42.2 ±5.6

FEV,, L

1.4±0.3

Sa02 awake, %

90.6 ±2.9

Other sleep/respiratory parameters are presented in Table 2. The very short mean total sleep time and the high arousal index are notable. Obstructive and central apnea indexes do not suggest the presence of clinically significant apnea. Of particular interest is the fact that eight of the patients had at least one MSLT nap with a latency of less than five minutes; however, the mean waking Pa02 of this group (62.9 mm Hg) was not appreciably different from the group as a whole (64.5 mm Hg). buy kamagra

Table 2—Sleep/Respiratory Measures

Mean ± SD

Total sleep time, h

4.3± 1.2

Obstructive apneas/h

5.4 ±10.1

Partial obstrnctions/h

11.0± 15.3

Central apneas/h

Arousal s/h

49.9 ±68.1

Lowest spontaneous Sa02*

81.1 ± 10.1

Lowest apnea-related Sa02t

70.6 ±9.8

MSLTt (mean latency, min)

11.0±3.7

MSLT naps with sleep latency <5 min (no.)

0.9 ±0.9

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