Comparative Studies on the In Vitro Decidualization Process in the Baboon (Papio anubis) and Human(1)
Decidualization involves the transformation of uterine stromal fibroblasts into fully differentiated decidual cells. Although the morphological and biochemical characteristics of the decidual cell have been extensively studied, the precise biochemical and molecular signals required for this transformation are unknown. Our group has focused on a nonhuman primate, the baboon, as a model for studying fetal-maternal interactions and endometrial responses associated with the establishment of pregnancy. cialis professional 20 mg
Insulin-like growth factor-binding protein-1 (IGFBP-1) is the major secretory product of the human and baboon decidualized endometrium and thus can be used as a biochemical marker of decidualization. In the human, de-cidualization begins at the end of each menstrual cycle and progresses if there is a pregnancy. Numerous studies have demonstrated decidualization of human endometrial stromal cells in vitro in the presence of hormones and growth factors. In the baboon, decidualization occurs only during pregnancy and requires the presence of a con-ceptus or a conceptus product. Decidualization cannot be induced in vivo with long-term estrogen and progesterone treatment alone.