A large-scale clinical trial comparing the ARB valsartan with the same ARB plus HCTZ revealed unexpected findings and raised new questions. The ARB/HCTZ combination lowered BP successfully but significantly increased the inflammatory marker hsCRP Professor Paul Ridker, MD, MPH, study author of the Val-MARC trial (POzlsartan: Managing BP Aggressively and Evaluating deductions in hsCRP) from […]
Aliskiren (Rasilez, Novartis), a direct renin inhibitor and the first in a new class of antihypertensive drugs to be introduced in a decade, has been submitted for approval by the Food and Drug Administration (FDA). In clinical trials presented at the American Society of Hypertension’s Annual Scientific Meeting and Exposition (ASH 2006), aliskiren provided uninterrupted […]
MULTIPLE SCLEROSIS SYMPOSIUM Long-term efficacy data for glatiramer acetate (Copaxone, Teva Pharmaceuticals), which is indicated for patients with multiple sclerosis (MS), constituted a centerpiece among two days of presentations at the Fifth Teva and Sanofi-Aventis International Symposium on MS. Several hundred interested professionals attended the meeting, which took place from May 12-14, in Tenerife, Spain.
Our study showed baseline differences among the non-hypertensive and hypertensive AAASPS enrollees. Specifically, the non-hypertensive African American enrollees were more likely to be current cigarette smokers and have higher education, and less likely to have old CT/MRI-based infarcts. On the other hand, hypertensive AAASPS enrollees, in addition to having htn, were more likely to have […]
Demographic and Factors (Table 1) The mean age of hypertensive and non-hypertensive patients was 62.3 ± 10.4 and 59.1 ± 12.5 years (p=0.064), respectively. Women comprised 54% of the hypertensive and 41% of the non-hypertensive patients (p=0.030). The mean education of hypertensives was 11.1 ±3.1 compared to 11.7 ± 2.9 of non-hypertensives (p=0.024). A history […]
MRI-based Infarcts and CT-based Infarcts MRI and CT scans were reviewed by AAASPS local principal investigators and/or local radiolo gists for evidence, location and size of recent and old cerebral infarctions. MRI and CT results were classified according to TOAST criteria.
Demographics and Cardiovascular Factors The database for this analysis was the AAASPS. AAASPS is an ongoing NIH-spon-sored, multi-center, randomized, double-blind clinical trial designed to compare the effect of ticlopidine and aspirin in the prevention of recurrent stroke, myocardial infarction, and vascular death in AAs with recent, noncardioembolic ischemic stroke. Eligibility criteria for the study have […]