The drugs of this class have been widely used in patients with calcium nephrolithiasis, more so in those presenting with idio­pathic hypercalciuria. Hydrochlorothiazide, chlortalidone or trichlormethiazide, alone or in association with amiloride, induce a significant reduction of calcium excretion, revert external balance of calcium to positive, and protect bone from demineralisation. Thiazides are able to [...]

The amazing advances in molecular genetics have also in­volved hypercalciuria, and at least three candidate genes were shown to arbour mutations leading to altered calcium excretion. The chloride channel 5 (ClC-5), the calcium sensing receptor and the paracellin-1 are proteins encoded by corresponding genes, whose mutations causing either loss or gain of function, lead to [...]

Introduction Idiopathic hypercalciuria is the most frequent metabolic abnor­mality since up to 40 to 60% of patients with nephrolithiasis are hypercalciuric. Fasting hypercalciuria, accompanies id­iopathic hypercalciuria in up to 50% of the patients. It is widely agreed that high calcium excretion may be causative for stone disease, because the higher calcium concentration, the higher the [...]

Pleural effusions in the yellow nail syndrome are thought to be secondary to dysfunction of pleural lymphatics. Once present, they tend to persist and may recur rapidly after therapeutic thoracentesis, making this an impractical option in many symptomatic patients. Chemical pleurodesis using quinacrine (Atabrine) and tetracycline has been successful in two patients. Nine patients have [...]

The data reported in this study do not support the notion of a strong relationship between hypoxemia per se and an objective measure of EDS in a group of patients with chronic daytime and nocturnal hypoxe­mia. Taken together, this group of patients with COPD did not reveal any evidence of subjective or objective EDS as [...]

Table 1 presents a comparison of the age, weight, and waking respiratory measures. Overall (n=14), there was no significant correlation between mean sleep onset latencies on the MSLT and waking Pa02 (- .13), PaC02 (.02), FEV, (.04), or mean spontaneous desaturation during sleep (.31). The mean sleep onset latencies were well within the published normal [...]

Fourteen male patients with stable COPD were randomly se­lected from the Chest Medicine Clinic at the Veterans Administra­tion Medical Center in Oklahoma City. Patients were selected without regard to the presence or absence of daytime sleepiness. The mean age was 60 years (range, 48 to 72 years). Patients were selected with a waking Pa02 of [...]