Atorvastatin calcium: PHARMACOKINETICS
the area under the plasma concentration-time curve (AUC), LDL-C reduction is similar when atorvastatin is given with and without food . Plasma atorvastatin concentrations are lower (approximately 30% for Cmax and AUC) following evening drug administration than following morning dosing . However, the reduction in LDL-C level is the same regardless of the time of drug administration.
Atorvastatin is extensively metabolized to ortho- and para-hydroxylated derivatives (by cytochrome P450 3A4) and various beta-oxidation products . Approximately 70% of circulating inhibitory activity for HMG-CoA reductase is attributed to active metabolites. Atorvastatin is eliminated primarily in bile following hepatic and/or extrahepatic metabolism; however, the drug does not appear to undergo significant enterohepatic recirculation . The mean plasma elimination half-life of atorvastatin is approximately 14 h (in contrast to 1 to 2 h for other HMG-CoA reductase inhibitors), but the half-life of inhibitory activity for HMG-CoA reductase is 20 to 30 h due to the contribution of longer-lived active metabolites . The kidney plays a minor role in the elimination of atorvastatin (less than 2% of a dose of atorvastatin is recovered in urine following oral administration). Find out more about your chance to get at best online pharmacy.