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  • Atorvastatin calcium: A new HMG-CoA reductase inhibitor(1)

Atorvastatin calcium: A new HMG-CoA reductase inhibitor(1)

Cardiovascular diseases remain the leading cause of death in Canada; 40% of all deaths are attributed to this disease category . Coronary artery disease (CAD) and cerebrovascular disease are the major components of cardiovascular disease. Although Canadian rates of CAD have fallen over the past few decades, they remain higher than the average in many parts of the world . CAD is the major cause of death in the elderly (aged 65 years and over); approximately 60% of all hospitalizations that are due to myocardial infarctions (MIs) occur in the elderly . CAD is also the leading cause of death in patients with diabetes; approximately 56% of diabetics die of CAD. Diabetics have two to four times the CAD risk of those without diabetes. Risk of CAD is further increased when diabetes is accompanied by dyslipidemia. Spend less money now – buy asthma inhaler for your efficient drug to cost less.

The Canadian Heart Health Survey estimated that 64% of the population (ages 18 to 74 years) have at least one of the major modifiable risk factors of cardiovascular disease: smoking, elevated cholesterol and high blood pressure . Approximately 20% of the population have two or more of the major risk factors, and 16% to 18% of the population have elevated levels of total blood cholesterol above 6.2 mmol/L and elevated levels of low density lipoprotein cholesterol (LDL-C) above 4.1 mmol/L. Individuals with the highest cholesterol levels appear to also have the highest prevalence of multiple risk factors . Studies in Canada and the United States have estimated that as much as 15% of cardiovascular mortality is attributable to elevated serum cholesterol level, equivalent to the proportion attributable to smoking and diabetes.

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