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  • A Retrospective Study

A Retrospective Study


Several million patients suffer from nonhealing wounds in a variety of anatomical sites, costing the health system millions of dollars. The cost and management of these wounds varies in different centers. For example, the cost of managing a diabetic foot infection for approximately two weeks in one center is between $20,000-$25,000 but may be quite different in another center. Prior to the advent of the wound VAC, the treatment of nonhealing wounds consisted of traditional modalities, such as wet-to-dry dressings, debridement, and topical antibiotics, with closure of these wounds taking several weeks or months. The process of wound healing is a complex one, consisting of cell migration leading to repair and closure of wounds. The process also needs removal of debris, control of infection, clearance of inflammation, angiogenesis, deposition of granulation tissue, contraction, remodeling of the connective tissue matrix, and maturation. If any of these steps fail, a chronic open wound without anatomical or functional integrity results. Chronic wounds may be associated with pressure, trauma, venous insufficiency, diabetes, arterial disease, or prolonged immobilization. These wounds result in prolonged hospitalization, high risk of infection, and result in billions of dollars in healthcare costs. The advent of the wound VAC has substantially increased wound closure rates and reduced morbidity and health costs for many patients. We present the clinical features, isolated pathogens, and healing results of 42 patients seen in our institution with sternal, spinal, and lower-extremity wounds treated with antimicrobial therapy, debridement, and wound VAC placement. cialis canadian pharmacy

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