A Comparison of Acquired Port-wine Stain
Port-wine stain (PWS) represents a type of congenital malformation involving mature dermal capillaries resulting in irreversible dilatation of capillaries. PWS is not only congenital but also acquired. All types are pathologically indistinguishable and represent progressive ectasia of vessels located in the superficial dermal plexus. In contrast to well-known congenital port-wine stain (CPWS), acquired port-wine stain (APWS) is rare and its onset is generally after one year of age. The exact patho-mechanism of APWS is unknown, but trau- ma hormonal change, medication, and solar damage may contribute to its development. Pulsed dye laser (PDL) therapy is regarded as the treatment of choice in PWS. Some scientific researchers reported that APWS patients responded more favorably to PDL therapy, and required fewer treatments than those with CPWS.
They proposed telangiectatic nature, relatively sparse number and superficial location of ectatic vessels as a cause of better response in APWS; however, at the same time, poor results in several patients were also reported by some authors. Generally, pathological parameters like vessel diameter, depth, and luminal erythrocytes contents were provided as evidence that could explain the difference in therapeutic outcome. Therefore it was thought that there might be some pathological differences between APWS and CPWS; however, no research has been conducted on this discrepancy to date. Thus, we undertook a project to reveal such histopathologic differences between APWS and CPWS, using a computer assisted image analysis. levitra 20 mg