Materials The skin biopsies of 31 patients before treatment were included in this study. The patients consisted of 14 APWS and 17 CPWS. The mean age was 26.7 years in APWS and 25.7 years in CPWS. In APWS, the ages of the onset were from 2 to 40. Con­firmation of the acquired nature of the [...]

INTRODUCTION Port-wine stain (PWS) represents a type of congenital malformation involving mature dermal capillaries resulting in irreversible dilatation of capillaries. PWS is not only congenital but also acquired. All types are pathologically indistinguish­able and represent progressive ectasia of vessels located in the superficial dermal plexus. In contrast to well-known congenital port-wine stain (CPWS), acquired port-wine [...]

Therapy is generally supportive and consists of emollients and cold compressives. In some cases, bullous acral lesions can preclude further use of the causative agent due to severe pain and impairment of function. When future cycles of the agent are necessary, patient-controlled analgesia, systemic methylprednisone, pyridoxine, and supportive topi­cal treatments have been used to treat [...]

Chemotherapy-induced acral erythema (CIAE) is a localized cutaneous reaction to chemotherapeutic agents administered in patients with either hema- tologic malignancies or solid tumors. It is charac­terized by symmetrical, well-demarcated, painful erythema on the palms and soles which may pro­gress to bullae formation and desquamation. Occa­sionally extension to periungual areas and over the dosa of the [...]

A 65-year-old man visited our hospital with a history of multiple palpable cervical lymph nodes for several months. The cervical lymph node biopsy was done and he was diagnosed as Non-Hodgkin’s lymphoma, diffuse large B-cell type, in November 2000. He was treated with combination chemo­therapy comprising 6 cycles of CHOP regimen (epirubicin, cyclophosphamide, vincristine and [...]

INTRODUCTION Chemotherapy-induced acral erythema (CIAE) is an uncommon toxic reaction to a number of dif­ferent chemotherapeutic agents. It is characterized by symmetrical, well-demarcated, painful erythema on the palms and soles which may progress to bullae formation and desquamation. The drugs most often involved in this eruption are fluorouracil, cytosine arabinoside and doxorubicin. CIAE with bullous [...]

Ossification of the skin occurs in various lesions. There are two major forms of cutaneous ossification. Primary cutaneous osteoma is a primary tumor without a preceding cutaneous lesion. And secon­dary ossification, that is secondary osteoma cutis, has preexisting lesions, such as pilomatricoma, basal cell carcinoma, acne, melanocytic nevi, cellular blue nevus, epidermal cyst, or malignant [...]